发明名称 |
PHTHALAZINONE DERIVATIVE AND PHARMACEUTICAL COMPRISING THE SAME |
摘要 |
<p>It is intended to provide a novel compound having an excellent PDE4 inhibitory activity and TNF-a production-suppressing activity. It is also intended to provide a preventive and therapeutic agent for atopic dermatitis or the like. The invention comprises a novel phthalazinone derivative represented by the following general structural formula [1], a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient. [Chemical formula 12] [1] In the structural formula [1], the following partial structure between positions 6 and 7 represents a single bond or a double bond. [Chemical formula 13] R<SUP>1</SUP> and R<SUP>2</SUP> represent alkyl or the like, Y represents phenylene or the like, Z represents alkylene or the like, R<SUP>3</SUP> represents a mono- to tri-cyclic saturated or unsaturated cyclic amino group or the like and R<SUP>31</SUP> and R<SUP>32</SUP> represent alkyl or the like.</p> |
申请公布号 |
WO2006115221(A1) |
申请公布日期 |
2006.11.02 |
申请号 |
WO2006JP308460 |
申请日期 |
2006.04.21 |
申请人 |
NIPPON SHINYAKU CO., LTD.;KAGAYAMA, KOHEI;ZHANG, XIN |
发明人 |
KAGAYAMA, KOHEI;ZHANG, XIN |
分类号 |
C07D237/32;A61K31/502;A61K31/5377;A61P1/04;A61P11/00;A61P11/02;A61P11/06;A61P17/00;A61P17/06;A61P27/14;A61P37/08;A61P43/00;C07D401/10;C07D403/10;C07D413/10;C07D491/113 |
主分类号 |
C07D237/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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