| 摘要 |
The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R<SUP>1 </SUP>alkyl units selected from the group consisting of C<SUB>1</SUB>-C<SUB>12 </SUB>linear or branched alkyl, C<SUB>3</SUB>-C<SUB>8 </SUB>cyclic alkyl, C<SUB>2</SUB>-C<SUB>12 </SUB>linear or branched alkenyl, or haloalkyl, for example, the 2-keto-3-alkylpiperazines having the formula: wherein R is selected from the group consisting of phenyl, 3-fluorophenyl, 4-fluorophenyl, 3,5-difluorophenyl, and 4-chlorophenyl; R<SUP>1 </SUP>is selected from the group consisting of methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclopropylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, benzyl, allyl, 1-methylallyl, 2-methylallyl, but-2-enyl, and propargyll; R<SUP>7a </SUP>is selected from the group consisting of hydrogen, -CO<SUB>2</SUB>H, -CONH<SUB>2</SUB>, -CONHCH<SUB>3</SUB>, and -CON(CH<SUB>3</SUB>)<SUB>2</SUB>; R<SUP>8 </SUP>is benzyl, substituted benzyl, or naphthalen-2-ylmethyl.
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