发明名称 Modulation of antibody effector function by hinge domain engineering
摘要 The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which alters the binding of Fc to one or more Fc ligand (e.g., FcγRs) and/or modulates effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more FcγR and/or C1q. Additionally, the Fc variants have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variants particularly for therapeutic purposes.
申请公布号 AU2006239851(A1) 申请公布日期 2006.11.02
申请号 AU20060239851 申请日期 2006.04.25
申请人 MEDIMMUNE, INC. 发明人 HERREN WU;WILLIAM DALL'ACQUA;JOSE CASA-FINET;MELISSA DAMSCHRODER
分类号 C07K16/00;A61K39/395;C07H21/04;C07K16/44;C07K17/00;C12N5/06;C12P21/06;C12P21/08 主分类号 C07K16/00
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