发明名称 |
Modulation of antibody effector function by hinge domain engineering |
摘要 |
The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which alters the binding of Fc to one or more Fc ligand (e.g., FcγRs) and/or modulates effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more FcγR and/or C1q. Additionally, the Fc variants have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variants particularly for therapeutic purposes. |
申请公布号 |
AU2006239851(A1) |
申请公布日期 |
2006.11.02 |
申请号 |
AU20060239851 |
申请日期 |
2006.04.25 |
申请人 |
MEDIMMUNE, INC. |
发明人 |
HERREN WU;WILLIAM DALL'ACQUA;JOSE CASA-FINET;MELISSA DAMSCHRODER |
分类号 |
C07K16/00;A61K39/395;C07H21/04;C07K16/44;C07K17/00;C12N5/06;C12P21/06;C12P21/08 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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