METHODS AND COMPOSITIONS FOR MODULATING WNT SIGNALING PATHWAY

摘要

This invention provides novel Wnt signaling pathway regulators. The invention also provides methods of using the Wnt signaling pathway regulators to screen for compounds that modulate Wnt signaling pathway. The methods comprise first screening test compounds for modulators of a Wnt signaling pathway regulator disclosed herein, and then further screening the identified modulating agents for ability to modulate Wnt signaling pathway. The invention further provides methods for modulating Wnt signaling pathway and pharmaceutical compositions for treating diseases and conditions (e.g., tumors) associated with abnormal Wnt signaling activities.