PROCESS FOR THE PREPARATION OF OLANZAPINE FORM 1 USEFUL AS ANTIPSYCHOTIC DRUG

摘要

This invention provides an improved process for the preparation of Olanzapine Form (I). Olanzapine, which is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazapine. More specially, the invention provides insitu improved process for the direct preparation of crystalline form of Olanzapine Form (I). The present invention also provides high pure Olanzapine Form I with single individual impurity less than 0.1% by HPLC.