A KIT FOR MEASURING THE THROMBIN GENERATION IN A SAMPLE OF A PATIENT'S BLOOD OR PLASMA
摘要
The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl<SUB>2</SUB>. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.
申请公布号
WO2005095638(B1)
申请公布日期
2006.11.02
申请号
WO2005EP03328
申请日期
2005.03.30
申请人
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;VARADI, KATALIN;TURECEK, PETER;KEIL, BRIGITTE;PEYRER-HEIMSTAETT, SYLVIA;SCHWARZ, HANS-PETER