发明名称 |
PREPARACOES QUE CONTEM PARTICULAS DO TIPO DE VIRUS COMO IMUNOESTIMULANTES ADMINISTRADOS ATRAVES DA MUCOSA |
摘要 |
<p>The present invention is related to the branch of medicine, particularly to the new formulations of vaccine antigens. The technical objective pursued with the present invention is, precisely, the development of formulations that are able to enhance the immune response to mucosally administered antigens, minimising the number of compounds in the formulation and generating strong mucosal and systemic responses through a synergic interaction between the antigens in the formulation. These formulations enable: a) to broaden the spectrum of the anti-hepatitis B immune response, containing as main compounds HBsAg and HBcAg, b) to enhance the response against HBsAg with a viral nucleocapsid c) to generate combined vaccines through the mucosal route with HBsAg as a central antigen. Stabilizers and preservatives can be introduced. The formulations of this invention can be applied in the pharmaceutical industry as human or veterinary vaccine formulations.</p> |
申请公布号 |
PT1136077(E) |
申请公布日期 |
2006.10.31 |
申请号 |
PT19990957844T |
申请日期 |
1999.12.01 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIG |
发明人 |
AGUILAR, RUBIDO JULIO CESAR;PALENZUELA GARDON, DANIEL OCTAVIO;MUZIO GONZALEZ, VERENA LUCILA;GUILLEN NIETO, GERARDO ENRIQUE;PENTON ARIAS, EDUARDO;PICHARDO DIAZ, DAGMARA;IGLESIAS PEREZ, ENRIQUE |
分类号 |
A61K39/29;A61K39/295;A61P37/04;(IPC1-7):A61K39/29 |
主分类号 |
A61K39/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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