发明名称 |
Laser desorption and ionization mass spectrometer with quantitative reproducibility |
摘要 |
Laser desorption/ionization time-of-flight mass spectrometer ("LDI-TOF-MS") devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.
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申请公布号 |
US7129483(B2) |
申请公布日期 |
2006.10.31 |
申请号 |
US20050155302 |
申请日期 |
2005.06.17 |
申请人 |
CIPHERGEN BIOSYSTEMS, INC. |
发明人 |
YOUNGQUIST MICHAEL G.;KELLER CRAIG A. |
分类号 |
B01D59/44;H01J49/00;H01J49/16;H01J49/40 |
主分类号 |
B01D59/44 |
代理机构 |
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主权项 |
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地址 |
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