摘要 |
The present invention relates to a peptide comprising the sequence R<SUB>1</SUB>-X<SUB>1</SUB>-X<SUB>2</SUB>-X<SUB>3</SUB>-X<SUB>4</SUB>-R<SUB>2</SUB>, wherein X<SUB>1 </SUB>is selected from the group consisting of N, Q, D and S; X<SUB>2 </SUB>is selected from the group consisting of V, I and L; X<SUB>3 </SUB>is selected from the group consisting of R and K; and X<SUB>4 </SUB>is selected from the group consisting of V, I, L and F; R<SUB>1 </SUB>is a hydrogen or a peptide of 1 to 6 amino acids, and acyl or an aryl group; and R<SUB>2 </SUB>is a peptide of 1 to 3 amino acids, a hydroxide or an amide. The invention also relates to partial or full retro-inverso peptides comprising the above sequences. The invention also relates to peptide-substrate combination comprising a substrate suitable for cell growth and the peptide of the invention, and to a vascular graft and an artificial blood vessel comprising the peptide-substrate combination. The invention also relates to a pharmaceutical composition and a peptide conjugate comprising the peptide of the invention. The invention also relates to a method of inhibiting adhesion of a cell expressing alpha3beta1 integrin to an cellular matrix, inhibiting alpha3beta1-integrin-mediated cell motility, inhibiting alpha3beta1-integrin mediated cell proliferation, promoting alpha3beta1-integrin mediated cell proliferation and inhibiting angiogenesis utilizing the peptides of the invention.
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