| 摘要 |
Beta taipoxin obtained the taipoxin component of the venom of the taipan snake, Oxyuranus s. scutellatus, was fragmented by trypsin digestion. The fragment which showed the highest activity on skin cells for mitogenic activity and on PC12 cells for neurite growth was named Oxynor peptide. This fragment consisted of 21 amino acids and had the sequence from the N-terminal: Lys Gly Gly Ser Leu Leu Asn Phe Ala Asn Leu Ile Glu Asn Asp Val Pro Ile Asp His Met. Synthetic Oxynor peptide was constructed using ten amino acids (Ser Leu Leu Asn Phe Ala Asn Leu Ile Glu) and five amino acids (Ser Leu Leu Asn Phe). Experimentally produced 4 mm punched wounds on the back of the mice were treated with the ten amino acid version of synthetic Oxynor peptide. The results showed complete closure of the wounds after six days, while the wounds of controls remained open. The histological examination of the skin around the wounds showed epidermis almost like normal skin.
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