发明名称 |
HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES THAT RECOGNIZE EPIDERMAL GROWTH FACTOR RECEPTOR (EGF-R); DIAGNOSTIC AND THERAPEUTIC USE |
摘要 |
The invention relates to new humanized and chimeric monoclonal antibodies that recognized EGF-R comprising an artificial sequence at least of the FRs of the heavy chain variable region of a human inmunoglobulin . The hypervariable regions of both monoclonal antibodies is the following amino acid sequence: light chain : CDR-1:-arg-ser-ser-gln-asn-ile-val-his-ser-asn-gly-asn-thr-tyr-leu- asp;CDR-2:- lys-val-ser-asn-arg-phe-ser; CDR-3:-phe-gln-tyr-ser-hys-val-pro-trp-thr. Hea vy chain: CDR-1:- asn-tyr-tyr-ile-tyr; CDR-2:-gly-ile-asn-pro-thr-ser-gly-gly-ser- asn - phe-asn- glu-lys-phe-lys-thr; CDR-3:-gln-gly-leu-trp-phe-asp- ser-asp-gly-arg-gly-phe - asp-phe. The antibodies can be used for therapeutical and diagnostic purposes.</ SDOAB>
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申请公布号 |
CA2332183(C) |
申请公布日期 |
2006.10.31 |
申请号 |
CA19952332183 |
申请日期 |
1995.11.17 |
申请人 |
CENTRO DE INMUNOLOGIA MOLECULAR |
发明人 |
RODRIGUEZ, ROLAND PEREZ;FRIAS, ERNESTO MORENO;DE ACOSTA DEL RIO, CRISTINA MARIA MATEO |
分类号 |
C12N5/12;G01N33/566;A61K38/00;A61K38/18;A61K39/395;A61P35/00;C07H21/04;C07K14/485;C07K14/52;C07K14/705;C07K14/71;C07K16/00;C07K16/28;C07K16/30;C07K16/46;C07K19/00;C12N15/02;C12N15/09;C12P21/08;C12R1/91;G01N33/574;G01N33/577 |
主分类号 |
C12N5/12 |
代理机构 |
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主权项 |
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