发明名称 |
Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof |
摘要 |
The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the present invention provides hydrophobic heparin conjugates that are prepared by covalently binding a polymer to heparin and a hydrophobic agent to the polymer. The hydrophobic heparin conjugates of the present invention maintain a good antithrombogenic effect and are insoluble in water due to their hydrophobicity, so they can be effectively used as coating agents for modifying the surfaces of medical devices.
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申请公布号 |
US7129224(B1) |
申请公布日期 |
2006.10.31 |
申请号 |
US20030333641 |
申请日期 |
2003.01.21 |
申请人 |
MEDIPLEX CORPORATION, KOREA |
发明人 |
BYUN YOUNG RO;MOON HYUN TAE |
分类号 |
A61K31/727;A61L33/10;A61L27/34;A61L33/00;C07K14/47;C08B37/00;C08B37/10;C08G81/00;C08L5/10;C09D105/10;C09J105/10 |
主分类号 |
A61K31/727 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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