| 摘要 |
Compound represented by structural formula (I) or a pharmaceutical acceptabl e salt thereof, wherein a is 0-3; b, d and a are 0-2; R is H, alkyl, F or -OR6; A is an optionally substituted oxime or hydrazone; d is not 0 and X is a bond, -C(O)-, -O-, -NR9-, -S(O)S, -N(R6)C(O)-, -C(O)N(R6)-, -OC(O)NR6-, -OC(=S)NR6-, -N(R6)C(=S)O-, -S(O)2N(R6 )- , -N(R6)S(O)2-, -N(R6)C(O)O-, -OC(O)- or -N(R6)C(O)NR7-; or d is 0 and X is a bond or -NR6 ; T is H, aryl, heterocycloalkyl or heteroaryl; Q is phenyl, napthyl or heteroaryl; R6 is H, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, and benzyl; R9 is R6 or -OR6, R6a, R7a, R8a and R9a are H or alkyl; Z is a nitrogen-containing heterocyclo group, e.g., piperidinyl, substituted by a heterocyclo- or heterocycloalkyl group; wherein phenyl, benzyl, aryl, heterocycloalkyl, heteroaryl and cycloalkyl groups are optionally substituted; methods of treating diseases such as asthma, cough, bronchospasm, depression, emesis, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed.
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