发明名称 Triple monoamine reuptake inhibitors for the treatment of chronic pain
摘要 The use of the compound of the compound of the general formula (I) or a pharmaceutically acceptable addition salt thereof or the N-oxide thereof, wherein: R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; R3 is CH2-X-R', wherein X is O, S, or NR"; wherein R" is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, -CO-alkyl; R4 is 3,4-methylenedioxyphenyl; or phenyl, benzyl, naphthyl, or heteroaryl, each of which may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl, aryl; for the manufacture of a medicament for the treatment, prevention or alleviation of chronic pain, such as inflammatory pain, neuropathic pain, fibromyalgia, or tension-type headache.
申请公布号 NZ536415(A) 申请公布日期 2006.10.27
申请号 NZ20030536415 申请日期 2003.05.27
申请人 NEUROSEARCH A/S 发明人 SCHEELKRUGER, JORGEN;BLACKBURN-MUNRO, GORDON JOHN
分类号 C07D451/02;A61K31/00;A61K31/46;A61K45/00;A61P1/02;A61P1/04;A61P3/02;A61P19/02;A61P21/00;A61P25/00;A61P25/02;A61P25/04;A61P25/24;A61P29/00;A61P31/12;A61P31/18;A61P35/00;A61P37/04;A61P37/06;A61P43/00;(IPC1-7):A61K31/46 主分类号 C07D451/02
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