Biosensors for detecting bond rupture

摘要

A biosensor with a separate oscillator and rupture detector. The biosensor includes a surface onto which bio-macromolecules are bound, the surface and bio-macromolecules being immersed in liquid, a bond rupture detector associated with the surface, and an oscillator associated with the liquid and spaced from the surface and arranged to produce waves in the liquid to cause bonds between the bio-macromolecules and the target substance to rupture. A surface plasmon resonance detector detects rupture of the bonds by changing the angle of reflected light that has minimum reflectance.