发明名称 Imidazole derivatives for modulating sodium channels
摘要 Use of a compound of formula (I) or of a pharmaceutically acceptable salt of this compound for preparing a medicament intended for a condition selected from the group consisting of the treatment or prevention of pain, the treatment of epilepsy, the treatment of cardiac rhythm disorders, the treatment of disorders linked with neurodegeneration, the treatment of depression and bipolar disorders and the treatment of irritable bowel syndrome is disclosed, wherein: R1 is selected from the list consisting of a linear or branched alkyl radical containing from 3 to 16 carbon atoms, a cycloalkylalkyl radical the cycloalkyl radical of which contains from 3 to 7 carbon atoms and the alkyl radical of which is linear or branched and contains from 1 to 6 carbon atoms, an aralkyl radical and a substituted aralkyl radical, where the substituted aralkyl is substituted from 1 to 3 times on the aryl group by substituents independently chosen from the list consisting of a halogen atom, a linear or branched alkyl containing from 1 to 6 carbon atoms and a linear or branched alkoxy radical containing from 1 to 6 carbon atoms; R2 is selected from the list consisting of a phenyl radical a substituted phenyl radical, a biphenyl radical and a substituted biphenyl radical, where the substituted phenyl radical is substituted from 1 to 3 times by one or more substituent independently chosen from the list consisting of a halogen atom, a linear or branched alkyl containing from 1 to 6 carbon atoms and an alkoxy radical containing from 1 to 6 carbon atoms, and where the substituted biphenyl is substituted from 1 to 4 times by one or more substituents independently chosen from the list consisting of a halogen atom, a linear or branched alkyl containing from 1 to 6 carbon atoms and a linear or branched alkoxy radical containing from 1 to 6 carbon atoms; and R3 represents a hydrogen atom or a linear or branched alkyl radical containing from 1 to 6 carbon atoms.
申请公布号 NZ529741(A) 申请公布日期 2006.10.27
申请号 NZ20020529741 申请日期 2002.06.14
申请人 SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S 发明人 BIGG, DENNIS;POMMIER, JACQUES;LIBERATORE, ANNE-MARIE
分类号 C07D233/06;A61K31/00;A61K31/415;A61K31/4164;A61K31/4174;A61P1/12;A61P9/06;A61P25/04;A61P25/08;A61P25/24;A61P25/28;C07D233/10;C07D233/54;(IPC1-7):A61K31/415;A61K31/416;A61K31/417 主分类号 C07D233/06
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