| 摘要 |
Disclosed herein are compounds of formula (I), wherein: R1 is optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; R2 is hydrogen, halo, trifluoromethyl, or cyano; R3 is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl; R4 and R5 are independently hydrogen or optionally substituted acyl; X is a covalent bond or lower alkylene optionally substituted by cycloalkyl; X1 is a covalent bond or alkylene; Y is a covalent bond or lower alkylene optionally substituted by hydroxy or cycloalkyl; and Z is -CºC-, -R6C=CR7- or -CHR6CHR7-, in which R6 and R7 at each occurrence are hydrogen or lower alkyl. These compounds are partial and full A1 adenosine receptor agonists, and are useful for treating various disease states, in particular the supraventricular tachycardias, emesis, angina, myocardial infarction and hyperlipidemia.
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