| 摘要 |
A method of synthesizing 7-silyl camptothecins and 7-silyl homocamptothecins of formula (I) is disclosed, which includes the step of mixing a camptothecin or a homocamptothecin having hydrogen at the C7 position with a silyl radical generator and a silyl radical precursor under conditions to generate a silyl radical -SiR1R2R3 wherein R1, R2 and R3 are independently a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, an aryl group, -(CH2)mR11 or SiR12R13R14, wherein m is an integer within the range of 1 through 10 and R11 is a hydroxy group, an alkoxy group, an amino group, an alkylamino group, a dialkylamino group, F, Cl, a cyano group, -SRc or a nitro group, and wherein R12, R13 and R14 are independently the same or different an alkyl group or an aryl group, and wherein the variables shown in formula (I) are as defined in the specification.
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