ASCORBATE BINDING PEPTIDES

摘要

The present invention provides binding peptides useful for identifying compounds capable of modulating biogenic amine GPCR activation; isolated nucleic acid sequences encoding the peptides; analogs of and antibodies to the peptides; methods using the peptides to identify compounds capable of modulating biogenic amine GPCR activation; exemplary test compounds useful to be screened using the method; methods for regulating biogenic amine GPCR activation; and methods for regulating ligand binding. Also provided are kits comprising a biogenic amine GPCR or a peptide having an amino acid sequence of the binding portion of the GPCR, or a test compound, or both, and instructions for use in identifying biogenic amine GPCR activation modulators or in modulating biogenic amine GPCR activation. Methods include identifying a compound that mediates binding of an adrenergic compound to an adrenergic receptor; processes for making compounds that effect binding of an adrenergic compound to an adrenergic receptor are also provided.