NOVEL CHEMICAL INHIBITORS OF NEUTROPHIL ACTIVATION THROUGH THE SAC-DEPENDENT PATHWAY

摘要

The present invention relates to a method of treating an inflammatory disorder in a subject. The method involves administering to a subject an effective amount of a compound that modulates soluble adenylyl cyclase, thereby treating the inflammatory disorder in the subject. The present invention also relates to a method of inhibiting respiratory burst in adherent neutrophils without inhibiting neutrophil degranulation in or bacterial killing by neutrophils. The method involves contacting adherent neutrophils with an effective amount of a compound that modulates soluble adenylyl cyclase.