发明名称 METHOD FOR AUGMENTING THE ABILITY OF T-CELLS AND OTHER CELLS FOR FIGHTING DISEASE AND INVADE DISEASED ORGANS, FOR ELEVATING CD3 ZETA AND TNF-ALPHA EXPRESSION IN T-CELLS, AND MIXING T-CELL BOOSTING DEVICES AND KIT PARTICULARLY USEFUL IN SUCH METHOD
摘要 A method and device for augmenting the ability of T-cells, NK cells and other body cells, of a patient for fighting disease and invading diseased tissue, and for elevating the level of CD3 zeta expression in T cells for better functioning of these T-cells and their augmented capability to eliminate cancer and infectious organisms, by exposing, for a predetermined exposure period, the first substance of T-cell or other cells to a second substance having a T-cell-boosting capability, such as, but not limited to CD3 zeta elevating capability, increased CXCR4, CD147, 67-kDa laminin receptor and/or any other key receptor in T-cells capability, increased tissue invasion capability, TNFa elevating capability, to augment the ability of the separated cells to fight the disease; and following the predetermined exposure period, reintroducing the first substance of T-cells back into the blood of the subject. The first substance is exposed to the second substance by mixing the two substances in a mixing device providing hermetically-sealed conditions effective to maintain sterility in both substances during the mixing and to maintain tissue culture conditions required for the cells viability thereof and for the required exposure period.
申请公布号 WO2006111967(A2) 申请公布日期 2006.10.26
申请号 WO2006IL00482 申请日期 2006.04.20
申请人 LEVITE, MIA 发明人 LEVITE, MIA
分类号 A61K35/14 主分类号 A61K35/14
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