METHOD AND COMPOSITION TO EVALUATE CYTOCHROME P450 2D6 ISOENZYME ACTIVITY USING A BREATH TEST

摘要

The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of <SUP>13</SUP>CO<SUB>2 </SUB>exhaled by a the subject upon intravenous or oral administration of a <SUP>13</SUP>C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite <SUP>13</SUP>CO<SUB>2</SUB> in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.