D-AMINO ACID DEHYDROGENASE AND METHOD OF MAKING D-AMINO ACIDS
摘要
Polypeptides capable of catalyzing the reductive amination of a 2-ketoacid to its corresponding D-amino acid are provided. The polypeptides can be prepared by mutagenesis of , e.g., a diaminopimelate dehydrogenase. Also provided is a method of making a D-amino acid using a catalytically active polypeptide, wherein a 2-ketoacid is allowed to contact the polypeptide in the presence of a nicotinamide cofactor and ammonia or an ammonia source.
申请公布号
WO2006113085(A2)
申请公布日期
2006.10.26
申请号
WO2006US11772
申请日期
2006.03.28
申请人
BIOCATALYTICS, INC.;ROZZELL, DAVID, J.;NOVICK, SCOTT, J.