PERKINSON DISEASE-RELATED GENE GRK5 AND USE THEREOF

摘要

As a result of a large scale SNP analysis on a group of Perkinson disease patients and a control group of normal persons, it has succeeded in the identification of a gene involved in Perkinson disease (GRK5). It is now found that the increase in the expression of the GRK5 gene induces the enhancement of the phosphorylation of a-synuclein, which in turn induces the enhancement of the formation of a soluble a-synuclein oligomer, leading to the development of Perkinson disease. It becomes possible to diagnose Perkinson disease and screen a therapeutic agent for Perkinson disease by using the expression of the GRK5 gene.