发明名称 |
Disease model animal carrying foreign ppar alpha gene transferred thereinto and use thereof |
摘要 |
The present invention provides a non-human mammal, or a part of its living body, which stably retains a DNA encoding a heterologous PPARalpha in an expressible state, and has one or more different genetic modifications resulting in a pathological condition identical or similar to a disease associated with the regulation of PPARalpha activity or a foreign DNA under the control of a promoter having PPRE, as well as a method of screening for agonists/antagonists for the heterologous PPARalpha using the animal.
|
申请公布号 |
US2006242716(A1) |
申请公布日期 |
2006.10.26 |
申请号 |
US20050521174 |
申请日期 |
2005.06.17 |
申请人 |
AMANO YUICHIRO;SUGIYAMA YASUO;NISHIDA MAYUMI;TAKETOMI SHIGEHISA |
发明人 |
AMANO YUICHIRO;SUGIYAMA YASUO;NISHIDA MAYUMI;TAKETOMI SHIGEHISA |
分类号 |
A01K67/027;A61P1/16;A61P3/04;A61P3/06;A61P3/10;A61P7/02;A61P7/06;A61P9/10;A61P9/12;A61P13/12;A61P15/00;A61P17/02;A61P25/28;A61P27/02;A61P35/00;A61P37/00;A61P43/00;C07K14/705;C12N15/85;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|