BIOREACTOR SYSTEM AND METHOD OF ENHANCING FUNCTIONALITY OF MUSCLE CULTURED IN VITRO
摘要
A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.
申请公布号
WO2006113382(A2)
申请公布日期
2006.10.26
申请号
WO2006US13963
申请日期
2006.04.13
申请人
WAKE FOREST UNIVERSITY HEALTH SCIENCES;YOO, JAMES;STITZEL, JOEL;ATALA, ANTHONY;CHRIST, GEORGE
发明人
YOO, JAMES;STITZEL, JOEL;ATALA, ANTHONY;CHRIST, GEORGE