发明名称 |
METHODS AND COMPOSITIONS TO MODULATE ADHESION AND STRESS TOLERANCE IN BACTERIA |
摘要 |
Methods and compositions are provided which improve the adhesion of a bacteria to target substrates and/or improve the stress tolerance of a bacteria. Methods comprise exposing bacteria to adhesion adaptive conditions and thereby increasing the adhesion activity and/or stress tolerance of the bacteria. Further provided are bacteria having a modulated production of autoinducer-2. Compositions include recombinant bacteria expressing nucleic acid molecules involved in the pathway of autoinducer-2 production. Further provided are autoinducer-2-related fusion proteins, antigenic peptides, antibodies, and vectors. Methods of screening compounds or environmental conditions which will stimulate the production of autoinducer-2 and/or produce an adhesion adaptive response are further provided, as are various methods of use for the bacteria having increased adhesion and/or stress tolerance. |
申请公布号 |
CA2605162(A1) |
申请公布日期 |
2006.10.26 |
申请号 |
CA20062605162 |
申请日期 |
2006.04.14 |
申请人 |
NORTH CAROLINA STATE UNIVERSITY |
发明人 |
ALTERMANN, ERIC;BUCK, B. LOGAN;AZCARATE-PERIL, ANDREA;KLAENHAMMER, TODD R. |
分类号 |
C12N1/36;A23L1/30;A61K35/74;C12N1/20;C12P9/00 |
主分类号 |
C12N1/36 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|