| 发明名称 |
HCV NS-3 SERINE PROTEASE INHIBITORS |
| 摘要 |
<p>Compounds of the formula where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.</p> |
| 申请公布号 |
EP1713823(A2) |
申请公布日期 |
2006.10.25 |
| 申请号 |
EP20050704765 |
申请日期 |
2005.01.28 |
| 申请人 |
MEDIVIR AKTIEBOLAG |
发明人 |
ROSENQUIST, ASA;THORSTENSSON, FREDRIK;JOHANSSON, PER-OLA;KVARNSTROEM, INGEMAR;SAMUELSSON, BERTIL;WALLBERG, HANS |
| 分类号 |
C07K5/02;A61K31/47;A61P31/12;C07C235/40;C07C237/04;C07C237/10;C07C247/04;C07C271/22;C07C281/02;C07C309/73;C07C311/51;C07D;C07D207/16;C07D215/22;C07D215/233;C07D245/04;C07D401/12;C07D405/14;C07D409/14;C07D413/14;C07D417/04;C07D417/14;C07D487/04;C07K5/06 |
主分类号 |
C07K5/02 |
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