Process for decreasing aggregate levels of pegylated protein
摘要
The present invention is directed generally to recombinant methods for making a desired pegylated protein and pooling of same. The method(s) yield a polypeptide product containing reduced levels of aggregate thereof pooled to provide the desired pegylated isoforms thereof.
申请公布号
ZA200502320(B)
申请公布日期
2006.10.25
申请号
ZA20050002320
申请日期
2003.09.22
申请人
PHARMACIA CORPORATION
发明人
BOYLE, DENIS M;BUCKLEY, JOHN J;JOHNSON, GARY V;STEIMEYER, DAVID E;TOAL, MICHELE;AYKENT, SERDAR;RATHORE, ANURAG S