发明名称 |
CDK2 ANTAGONISTS AS SHORT FORM C-MAF TRANSCRIPTION FACTOR ANTAGONISTS FOR TREATMENT OF GLAUCOMA |
摘要 |
The short form version of c-Maf transcription factor is up-regulated in steroid-treated and transforming growth factor beta2-treated trabecular meshwork cells, and is present at elevated levels in glaucomatous versus normal trabecular meshwork cells and in glaucomatous versus normal optic nerve head tissue. Expression of short form c-Maf transcription factor under these conditions indicates a causal or effector role for the factor in primary open-angle and steroid- induced glaucoma pathogenesis. Antagonism of short form c-Maf transcription factor expression and/or activity in the trabecular meshwork or other ocular tissue is provided for inhibiting or alleviating glaucoma pathogenesis. Antagonists include cyclin-dependent kinase 2 inhibitors.
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申请公布号 |
KR20060110301(A) |
申请公布日期 |
2006.10.24 |
申请号 |
KR20067010098 |
申请日期 |
2006.05.24 |
申请人 |
ALCON, INC. |
发明人 |
SHEPARD ALLAN R.;JACOBSON NASREEN;CLARK ABBOT F. |
分类号 |
A61K31/52;A61K31/00;A61K31/519 |
主分类号 |
A61K31/52 |
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