发明名称 |
Bicyclic carbohydrate compounds useful in the treatment of infections caused by Flaviviridae sp., such as hepatitis C and bovine viral diarrhea viruses |
摘要 |
We describe the use of bicyclic carbohydrates for the treatment of hepatitis C virus infections. Different bicyclic carbohydrates were tested in vitro against DNA-viruses, retro-viruses and Flaviviridae sp., an important family of human and animal RNA pathogens. Significant activity was observed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), the bicyclic carbohydrates in general and the preferred bicyclic carbohydrates more specifically are expected to be a treatment for hepatitis C viral infections.
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申请公布号 |
US7125853(B2) |
申请公布日期 |
2006.10.24 |
申请号 |
US20030743111 |
申请日期 |
2003.12.22 |
申请人 |
KEMIN PHARMA B.V.B.A. |
发明人 |
SAS BENEDIKT;VAN HEMEL JOHAN;VANDENKERCKHOVE JAN;PEYS ERIC;VAN DER EYCKEN JOHAN;RUTTENS BART;BALZARINI JAN;DE CLERCQ ERIC;NEYTS JOHAN |
分类号 |
A01N43/04;A01N43/16;A61K31/35;A61K31/357;A61K31/385;A61K31/519;A61K31/70 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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