发明名称 Use of pyrimidine-or triazine-2 carbonitiles for treating diseases associated with cysteine prostease activity and novel pyrimidine-2-carbonitile derivatives
摘要 The present invention therefore provides use of a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition, this invention also discloses processes for the preparation of such inhibitors
申请公布号 US7125881(B2) 申请公布日期 2006.10.24
申请号 US20040518817 申请日期 2004.12.20
申请人 ASTRAZENECA AB 发明人 BAILEY ANDREW;PAIRAUDEAU GARRY;PATEL ANIL;THOM STEPHEN
分类号 A61K31/505;A61K31/506;A61K31/53;A61K31/5377;A61P9/00;A61P11/00;A61P11/06;A61P19/02;A61P19/10;A61P25/00;A61P25/28;A61P29/00;A61P37/00;A61P43/00;C07D239/42;C07D239/46;C07D239/48;C07D239/50;C07D251/18;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D405/04;C07D405/12;C07D413/14;C07D487/08 主分类号 A61K31/505
代理机构 代理人
主权项
地址