PREPARATION OF PHARMACEUTICAL SALTS OF [1,4]-BIPIPERIDINE

摘要

The invention provides anhydrous and hydrated forms of sodium salt of N-[ [4- (3, 4-dichlorophenoxy) [1, 4'-bipiperidin] -1'-yl]carbonyl]-4-methyl -benzenesulfonamide and crystalline forms of N- [[4-(3,4-dichlorophenoxy) [1,4' - bipiperidin]- 1' -yl]carbonyl] -4-methyl-benzenesulfonamide; and such compounds are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.