发明名称 |
Immunomodulatory steroids, in particular the hemihydrate of 16, alpha.-bromoepiandrosterone |
摘要 |
<p>The invention provides compositions comprising formula 1 steroids, e.g., 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one hemihydrate and one or more excipients, typically wherein the composition comprises less than about 3% water. The compositions are useful to make improved pharmaceutical formulations. The invention also provides methods of intermittent dosing of steroid compounds such as analogs of 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one and compositions useful in such dosing regimens. The invention further provides compositions and methods to inhibit pathogen (viral) replication, ameliorate symptoms associated with immune dysregulation and to modulate immune responses in a subject using certain steroids and steroid analogs. The invention also provides methods to make and use these immunomodulatory compositions and formulations.</p> |
申请公布号 |
HK1046002(A1) |
申请公布日期 |
2006.10.20 |
申请号 |
HK20020106613 |
申请日期 |
2002.09.09 |
申请人 |
HOLLIS-EDEN PHARMACEUTICALS, INC. |
发明人 |
CLARENCE NATHANIEL AHLEM;JAMES MARTIN FRINCKE;LUIS DANIEL DOS ANJOS DE CARVALHO;WILLIAM HEGGIE;PRENDERGAST, PATRICK, T.;READING, CHRISTOPHER, L.;KRUPAKAR PAUL THADIKONDA;RUSSELL NEIL VERNON |
分类号 |
A61K31/565;A61K31/5685;A61K31/58;A61P31/04;A61P31/12;A61P31/18;A61P31/20;A61P33/00;A61P35/00;A61P37/00;C07J1/00;C07J3/00;C07J9/00;C07J17/00;C07J53/00;C07J73/00;(IPC1-7):C07J;A61K |
主分类号 |
A61K31/565 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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