INFLUENZA VIRUS A/17/WYOMING/03/8 (H3N2) STRAIN FOR PRODUCTION OF LIVING INFLUENZA INTRANASAL VACCINE FOR INFANTS AND ADULTS

摘要

FIELD: virology, medicine. ^ SUBSTANCE: claimed strain is obtained by genetic reassortment of A/Wyoming/3/03 (H3N2) epidemic virus with cold adapted A/Leningrad/134/17/57 (H2N2) strain, which represents attenuation donor, followed by selection in presence of serum for A/Leningrad/134/17/57 (H2N2) virus. Obtained strain is temperature sensitive and cold adapted. Reassortant has taken over epidemic virus two genes encoding hemagglutinine and neuraminidase surface proteins and six genes encoding non-glycosilated proteins from attenuation donor. ^ EFFECT: new strain for production of living influenza intranasal vaccine for infants and adults. ^ 1 dwg, 3 tbl, 2 ex