发明名称 |
Novel n-acetylglucosamine transferase, nucleic acid encoding the same, antibody against the same and use thereof for diagnosing cancer or tumor |
摘要 |
Described are an enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through a beta1,3-linkage; nucleic acid coding for the enzyme; and method for diagnosis of a cancer and/or tumor, especially a cancer and/or tumor of a digestive organ using the expression amount of the gene of the enzyme as an index. A gene coding for a novel enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through the beta1,3-linkage was cloned from human colon and stomach cells, and the gene was sequenced. The enzyme was expressed, and a monoclonal antibody to the enzyme was prepared. Since this enzyme is not produced substantially or at all in cancer and/or tumor cells, especially in cancer or tumor cells of a digestive organ, the cancer and/or tumor may be diagnosed using the expression of the gene of the enzyme as an index.
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申请公布号 |
US2006234220(A1) |
申请公布日期 |
2006.10.19 |
申请号 |
US20040492819 |
申请日期 |
2004.11.08 |
申请人 |
NARIMATSU HISASHI;INABA NIRO;IWAI TOSHIE |
发明人 |
NARIMATSU HISASHI;INABA NIRO;IWAI TOSHIE |
分类号 |
C12Q1/68;C07H21/04;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N9/10;C12N15/54;C12P21/06;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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