发明名称 |
Novel guanosine derivatives and use thereof |
摘要 |
It is intended to provide a novel monomer unit by which Z type DNA can be more effectively stabilized, a reagent for integrating this monomer unit into an oligonucleotide, and a method of stabilizing Z type DNA by using the reagent. Namely, a guanosine derivative represented by the following general formula [1]: wherein R<SUP>1 </SUP>represents acyl; R<SUP>2 </SUP>represents lower alkyl; R<SUP>3 </SUP>represents tri-substituted silyloxy or tetrahedropyranyloxy; and R<SUP>4 </SUP>represents cyanoethyl or allyl; a reagent for stabilizing Z type DNA which contains the guanosine derivative; and a method of stabilizing Z type DNA by using the guanosine derivative. It is also intended to provide a method of transferring guanosine having lower alkyl at the 8-position into an oligonucleotide by using the guanosine derivative; and an oligonucleotide carrying guanosine having lower alkyl at the 8-position transferred thereinto.
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申请公布号 |
US2006235219(A1) |
申请公布日期 |
2006.10.19 |
申请号 |
US20050546107 |
申请日期 |
2005.08.18 |
申请人 |
SUGIYAMA HIROSHI;XU YAN;IKEDA REIKO |
发明人 |
SUGIYAMA HIROSHI;XU YAN;IKEDA REIKO |
分类号 |
C07H19/04;C12N15/09;C07H19/167;C07H21/04 |
主分类号 |
C07H19/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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