发明名称 |
ENZYME-CHANNELING BASED ELECTROCHEMICAL BIOSENSORS |
摘要 |
Low-cost, non-toxic and fast immunoassay systems (immunosensors) and uses thereof as analytical and diagnostic tools for detecting an immune response in a subject are disclosed. The systems and methods disclosed are based on recording an electrochemical signal which is generated proportionally to an enzymatic cascade reaction (enzyme-channeling) upon detecting an analyte, and therefore can be used to determine the titer level of an antibody analyte in a liquid sample such as artificial media, serum or blood both qualitatively and quantitatively, in a one-step and separation free immunoassay. Systems and methods based on recording an electrochemical signal which is generated proportionally to an enzymatic cascade reaction (enzyme-channeling) upon detecting an analyte, which utilize a non-toxic secondary substrate such as acetaminophen are also disclosed. |
申请公布号 |
WO2006109311(A2) |
申请公布日期 |
2006.10.19 |
申请号 |
WO2006IL00466 |
申请日期 |
2006.04.11 |
申请人 |
RAMOT AT TEL AVIV UNIVERSITY LTD.;RISHPON, JUDITH;NEUFELD, TOVA |
发明人 |
RISHPON, JUDITH;NEUFELD, TOVA |
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