MODULATION OF AN IMMUNE RESPONSE BY FILAMENTOUS HAEMAGGLUTININ

摘要

Described is a method for modulating an immune response, the method comprising administering filamentous haemagglutinin (FHA) or a derivative or mutant or fragment or variant or peptide thereof . IL-17 has been shown to be an important pro-inflammatory mediator which results in pathology in autoimmune disease. FHA has been shown to suppress IL-23 and IL-27 production. The suppression of these cytokines in turn suppresses the clonal expansion of IL-17 producing T cells. The suppression of IL-17 producing T cells results in a downregulation of IL-17 cytokine production.