A CHEMOENZYMATIC PROCESS FOR THE STEREOSELECTIVE PREPARATION OF (R)-GAMMA-AMINO-BETA-HYDROXYBUTYRIC ACID ((R) -GABOB) AND (R)-CARNITINE
摘要
<p>The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparation of racemic 3-hydroxy-4-tosyloxybutanenitrile, its lipase-mediated kinetic resolution and its successful application in the preparation of (R)-GABOB and (R)-carnitine.</p>
申请公布号
WO2006109322(A1)
申请公布日期
2006.10.19
申请号
WO2005IN00387
申请日期
2005.11.29
申请人
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH;KAMAL, AHMED;KHANNA, GOLLAPALLI BHASKER RAMESH;KRISHNAJI, TADIPARTHI;RAMU, RONDLA