VACCINE DELIVERY SYSTEM

摘要

An isolated protein comprising a hepatitis B surface antigen (HBsAg) amino acid sequence, and encoding nucleic acid, are provided wherein one or more immunogenic T cell epitopes of the HBsAg are respectively substituted with one of more immunogenic T cell epitopes of a protein other than HBsAg. Typically, the T cell epitopes are of a pathogen or tumour protein. The isolated protein may have endogenous HBsAg epitopes substituted with multiple copies of the same epitope or with different HBsAg epitopes. B cell epitopes may also be present. Also provided are expression constructs, VLPs, compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of diseases including human papillomavirus, respiratory syncytial virus, human immunodeficiency virus (HIV), cytomegalovirus (CMV), Epstein Barr virus (EBV), rotavirus, hepatitis B virus, parainfluenza virus, hepatitis C virus, Plasmodium falciparum, influenza virus, Mycobacterium tuberculosis measles virus and human metapneumovirus.