发明名称 |
Process for the preparation of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles |
摘要 |
The present invention is directed to a processes for the synthesis of trans isomer of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles (Formula I). The process comprises the steps of: (a) obtaining a compound of Formula II, which is a mixture of cis and trans-diastereomers, and (b) chemically decomposing the compound of Formula II in a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula I is obtained. The compounds prepared by the present invention are useful in treating diseases or conditions associated with platelet aggregation and/or platelet activation.
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申请公布号 |
US2006234976(A1) |
申请公布日期 |
2006.10.19 |
申请号 |
US20060393374 |
申请日期 |
2006.03.30 |
申请人 |
WATSON PAUL S;DOUGLASS JAMES G III;SUCHOZAK BOB;PANDIARAJU SUBRAMANIAN;DIXON CRAIG E;LEVIN DANIEL |
发明人 |
WATSON PAUL S.;DOUGLASS JAMES G.III;SUCHOZAK BOB;PANDIARAJU SUBRAMANIAN;DIXON CRAIG E.;LEVIN DANIEL |
分类号 |
A61K31/7076;A61K31/675;A61K31/7072;C07F9/6512 |
主分类号 |
A61K31/7076 |
代理机构 |
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地址 |
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