TRIAZOLE DERIVATIVE AND THE USE THEREOF

摘要

The invention relates to a thrombin receptor antagonist comprising a compound represented by the formula (I): (I) (wherein R<SUP>1a</SUP>, R<SUP>1b</SUP> and R<SUP>2</SUP> independently represent a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted or alkoxy which may be substituted, R<SUP>3</SUP> represents a group represented by any of the formulae, -NHCOR<SUP>4</SUP>, -NHSO<SUB>2</SUB>R<SUP>5</SUP>, -NHCON(R<SUP>6a</SUP>)(R<SUP>6b</SUP>), -NHCOOR<SUP>7</SUP> and -CONHR<SUP>8</SUP> (wherein R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6a</SUP>, R<SUP>6b</SUP>, R<SUP>7</SUP> and R<SUP>8</SUP> independently represent a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted or the like), the ring A represents a monocyclic aromatic ring which may further have a substituent, R<SUP>1a</SUP> and R<SUP>1b</SUP> may be bound to each other to form a nitrogen-containing nonaromatic heterocyclic ring which may be substituted), or a salt thereof or a prodrug thereof. The thrombin receptor antagonist of the invention has a thrombin receptor (particularly PAR-1) antagonism and is useful for preventing or treating PAR-1 associated pathologic conditions or diseases.