Novel clerodanes and methods for repelling arthropods

摘要

A method for repelling arthropods involving treating a subject or an object with an arthropod repelling composition containing an arthropod repelling effective amount of at least one clerodane of the formula in which R¹ is H, halogen, formyl, a straight chain or branched C_1-4 saturated alkyl, a straight chain or branched C_2-4 unsaturated alkyl, or an aryl containing 6-10 carbon atoms in the ring skeleton thereof, wherein R¹ is unsubstituted or substituted with one or more substituents, which are the same or different, selected from the group consisting of oxo (-O), OR², CO₂R², and OC(O)R², wherein R² is H, a straight chain or branched C_1-30 saturated alkyl, a straight chain or branched C_2-30 unsaturated alkyl, or an aryl comprising 6-10 carbon atoms in the ring skeleton thereof; wherein R² is unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, amino, hydroxyl, oxo (-O), thio, cyano and nitro; optionally a carrier, optionally an arthropod repellant, and optionally an insecticide. Preferably the compound is 13,14,15,16-tetranorclerod-3-en-12-al (callicarpenal), 13,14,15,16-tetranorclerod-3-en-12-ol, 13,14,15,16-tetranorclerod-3-en-12-oic acid, beta-epoxycallicarpenal, alpha-epoxycallicarpenal, or mixtures thereof. Also a compound of the above formula. Also an arthropod repellant composition containing an arthropod repelling effective amount of at least one of the compounds of the above formula and a carrier.