| 发明名称 |
COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF |
| 摘要 |
The present invention provides novel beta-secretase inhibitors of the genera l formula (I), where the variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, a method for their use in treating Alzheimer's disease, and methods for their use in reducing memapsin 2 catalytic activity.
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| 申请公布号 |
CA2604291(A1) |
申请公布日期 |
2006.10.19 |
| 申请号 |
CA20062604291 |
申请日期 |
2006.04.10 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;OKLAHOMA MEDICAL RESEARCH FOUNDATION;PURDUE RESEARCH FOUNDATION;COMENTIS, INC. |
发明人 |
KUMARAGURUBARAN, NAGASWAMY;SWANSON, LISA;ANKALA, SUDHA;GHOSH, ARUN K.;BILCER, GEOFFREY;TANG, JORDAN;LEI, HUI;DEVASAMUDRAM, THIPPESWAMY;LIU, CHUNFENG |
| 分类号 |
C07C233/78;A61K31/166;A61K31/18;A61P25/28;C07C311/08;C07C311/29;C07D207/09;C07D209/14;C07D211/26;C07D213/40;C07D213/61;C07D213/65;C07D213/74;C07D215/12;C07D241/12 |
主分类号 |
C07C233/78 |
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