PROCESSES FOR THE PREPARATION OF LINEZOLID INTERMEDIATE
摘要
The present invention provides improved methods of converting R-N-(4-morpholiyl- 3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl azide (III) to the intermediate S-N-(4- morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl amine (II) that involve the production of fewer by-products than previous methods. The amine (II) may then be converted into linezolid (I) of high chemical purity with respect to the inactive R- enantiomer and bis-linezolid (IV), and is in high yield, without the need for tedious, complicated purification steps, such as chromatography.
申请公布号
WO2006091731(A3)
申请公布日期
2006.10.19
申请号
WO2006US06414
申请日期
2006.02.23
申请人
TEVA PHARMACEUTICAL INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;FINE, SERGUEI;NIDAM, TAMAR;BRAUDE, VIVIANA