| 摘要 |
Chelating compounds for labeling bioactive molecules with a radiometal, having general formula (I) in which: both Y groups may be positioned either trans as shown or cis; A is an effector molecule, such as a peptide, in particular octreotide, CCK, substance P, gastrine, a protein, in particular an antibody or enzyme, sugars or radiosensitizing agents, like doxorubicin; R is a hydrogen, a C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl or a alcohol; X is a spacer, in particular (CH<SUB>2</SUB>)<SUB>n</SUB>-X', in which n is 1-10 and X' is COOH, NH<SUB>2</SUB>, SH, OH or O-halogen, in which halogen is in particular Br, I or Cl, or a molecule of the formula (a) or of the formula (b), Y is COO-, CH<SUB>2</SUB>CONH<SUB>2</SUB>, CH<SUB>2</SUB>CH<SUB>2</SUB>OH, optionally complexed with a radiometal.
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