发明名称 |
Intravenous nanoparticles for targeting drug delivery and sustained drug release |
摘要 |
Provided are poly(lactic-co-glycolic acid) (PLGA) and poly(lactic acid) (PLA) nanoparticles that encapsulate a low molecular weight and water-soluble drug and can deliver the drug to target legion sites where the particles gradually release the drug over a prolonged period of time. The nanoparticles are prepared by allowing the low-molecular, water-soluble and non-peptide drug to interact with a metal ion so as to make the drug hydrophobic, encapsulating the hydrophobicized drug into PLGA or PLA nanoparticles, and allowing a surfactant to be adsorbed onto the surface of the particles.
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申请公布号 |
US2006233883(A1) |
申请公布日期 |
2006.10.19 |
申请号 |
US20050550990 |
申请日期 |
2005.09.26 |
申请人 |
ISHIHARA TSUTOMU;MIZUSHIMA YUTAKA |
发明人 |
ISHIHARA TSUTOMU;MIZUSHIMA YUTAKA |
分类号 |
A61K9/50;A61K9/16;A61K9/51;A61K31/573;A61K33/24;A61K33/26;A61K33/34 |
主分类号 |
A61K9/50 |
代理机构 |
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