发明名称 |
USE OF TRANSTHYRETIN PEPTIDE/PROTEIN FUSIONS TO INCREASE THE SERUM HALF-LIFE OF PHARMACOLOGICALLY ACTIVE PEPTIDES/PROTEINS |
摘要 |
The present invention provides a means for increasing the serum half-life of a selected biologically active agent by utilizing transthyretin (TTR) as a fusion partner with a biologically active agent. Specifically, the present invention provides substantially homogenous preparations of TTR (or a TTR variant)-biologically active agent fusions and PEG-TTR (PEG-TTR variant)-biologically active agent fusions. As compared to the biologically active agent alone, the TTR-biologically active agent fusion and/or PEG-TTR-biologically active agent fusion has substantially increased serum half-life. |
申请公布号 |
EP1496926(A4) |
申请公布日期 |
2006.10.18 |
申请号 |
EP20030721538 |
申请日期 |
2003.04.03 |
申请人 |
AMGEN INC. |
发明人 |
WALKER, KENNETH;XIONG, FEI |
分类号 |
A61K38/00;C12N15/09;A61K38/17;A61K38/44;A61K47/32;A61K47/34;A61K47/36;A61K47/42;A61K47/48;A61P3/10;A61P7/04;C07K14/435;C07K14/475;C07K14/605;C07K17/08;C07K19/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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