INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE
摘要
The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing theses compounds.
申请公布号
EP1711515(A2)
申请公布日期
2006.10.18
申请号
EP20050712717
申请日期
2005.02.04
申请人
VERTEX PHARMACEUTICALS INCORPORATED
发明人
COTTRELL, KEVIN, M.;COURT, JOHN, J.;DEININGER, DAVID, D.;FARMER, LUC, J.;PITLIK, JANOS;PERNI, ROBERT B.